abstract：:Cancer stem-like cells (CSC) may be critical to maintain the malignant behavior of solid and hematopoietic cancers. Recently, patients with endometrial cancer whose tumors expressed high levels of aldehyde dehydrogenase (ALDH), a detoxifying enzyme characteristic of many progenitor and stem cells, exhibited a relative...

journal_title：Cancer research

authors： van der Zee M,Sacchetti A,Cansoy M,Joosten R,Teeuwssen M,Heijmans-Antonissen C,Ewing-Graham PC,Burger CW,Blok LJ,Fodde R

更新日期：2015-09-01 00:00:00

abstract：:Mitochondria are the powerhouses of cells. Mitochondrial C-Raf is a potential cancer therapeutic target, as it regulates mitochondrial function and is localized to the mitochondria by its N-terminal domain. However, Raf inhibitor monotherapy can induce S338 phosphorylation of C-Raf (pC-Raf(S338)) and impede therapy. T...

journal_title：Cancer research

authors： Tsai YT,Chuang MJ,Tang SH,Wu ST,Chen YC,Sun GH,Hsiao PW,Huang SM,Lee HJ,Yu CP,Ho JY,Lin HK,Chen MR,Lin CC,Chang SY,Lin VC,Yu DS,Cha TL

更新日期：2015-09-01 00:00:00

abstract：:In acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA) treatment induces granulocytic maturation and complete remission of leukemia. microRNAs are known to be critical players in the formation of the leukemic phenotype. In this study, we report downregulation of the miR-181a/b gene cluster in APL blasts...

journal_title：Cancer research

authors： Bräuer-Hartmann D,Hartmann JU,Wurm AA,Gerloff D,Katzerke C,Verga Falzacappa MV,Pelicci PG,Müller-Tidow C,Tenen DG,Niederwieser D,Behre G

更新日期：2015-08-15 00:00:00

abstract：:Cancer cells commonly display aberrant surface glycans and related glycoconjugate scaffolds. Compared with their normal counterparts, cancer cell glycans are variably produced and often structurally distinct, serving as biomarkers of cancer progression or as functional entities to malignancy. The glycan signature of a...

journal_title：Cancer research

authors： Dimitroff CJ

更新日期：2015-08-15 00:00:00

abstract：:An accurate intraoperative identification of malignant tissue is a challenge in the surgical management of breast cancer. Imaging techniques that help address this challenge could contribute to more complete and accurate tumor excision, and thereby help reduce the current high reexcision rates without resorting to the...

journal_title：Cancer research

authors： Kennedy BF,McLaughlin RA,Kennedy KM,Chin L,Wijesinghe P,Curatolo A,Tien A,Ronald M,Latham B,Saunders CM,Sampson DD

更新日期：2015-08-15 00:00:00

abstract：:Despite its function as an inhibitor of urokinase and tissue-type plasminogen activator (PA), PA inhibitor-1 (PAI-1) has a paradoxical protumorigenic role in cancer, promoting angiogenesis and tumor cell survival. In this review, we summarize preclinical evidence in support of the protumorigenic function of PAI-1 that...

journal_title：Cancer research

authors： Placencio VR,DeClerck YA

更新日期：2015-08-01 00:00:00

abstract：:Glioblastoma (GBM) is often treated with the cytotoxic drug temozolomide, but the disease inevitably recurs in a drug-resistant form after initial treatment. Here, we report that in GBM cells, even a modest decrease in the mismatch repair (MMR) components MSH2 and MSH6 have profound effects on temozolomide sensitivity...

journal_title：Cancer research

authors： McFaline-Figueroa JL,Braun CJ,Stanciu M,Nagel ZD,Mazzucato P,Sangaraju D,Cerniauskas E,Barford K,Vargas A,Chen Y,Tretyakova N,Lees JA,Hemann MT,White FM,Samson LD

更新日期：2015-08-01 00:00:00

abstract：:Prostate cancer is highly sensitive to hormone therapy because androgens are essential for prostate cancer cell growth. However, with the nearly invariable progression of this disease to androgen independence, endocrine therapy ultimately fails to control prostate cancer in most patients. Androgen-independent acquisit...

journal_title：Cancer research

authors： Cerasuolo M,Paris D,Iannotti FA,Melck D,Verde R,Mazzarella E,Motta A,Ligresti A

更新日期：2015-08-01 00:00:00

abstract：:The discovery of oncogenic driver mutations and the subsequent developments in targeted therapies have led to improved outcomes for subsets of lung cancer patients. The identification of additional oncogenic and drug-sensitive alterations may similarly lead to new therapeutic approaches for lung cancer. We identify an...

journal_title：Cancer research

authors： Tanizaki J,Ercan D,Capelletti M,Dodge M,Xu C,Bahcall M,Tricker EM,Butaney M,Calles A,Sholl LM,Hammerman PS,Oxnard GR,Wong KK,Jänne PA

更新日期：2015-08-01 00:00:00

abstract：:Oncogenic K-Ras mutation occurs frequently in several types of cancers, including pancreatic and lung cancers. Tumors with K-Ras mutation are resistant to chemotherapeutic drugs as well as molecular targeting agents. Although numerous approaches are ongoing to find effective ways to treat these tumors, there are still...

journal_title：Cancer research

authors： Fujita-Sato S,Galeas J,Truitt M,Pitt C,Urisman A,Bandyopadhyay S,Ruggero D,McCormick F

更新日期：2015-07-15 00:00:00

abstract：:Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably lymphangiogenic and represent a clear example of a cancer that utilizes the lymphatic vasculat...

journal_title：Cancer research

authors： Doçi CL,Mikelis CM,Lionakis MS,Molinolo AA,Gutkind JS

更新日期：2015-07-15 00:00:00

abstract：:Tumor resistance to cytotoxic drugs is one of the main obstacles to successful cancer therapy. Emerging evidence suggests that chemoresistance is promoted by substances released from dead and damaged cells that activate the host repair program orchestrated by Toll-like receptor-4 (TLR4). TLR4 is often overexpressed in...

journal_title：Cancer research

authors： Ran S

更新日期：2015-06-15 00:00:00

abstract：:Cell aggregation is frequently impaired during the growth of primary tumors and the formation of metastatic lesions. Cell aggregation depends on cell-cell adhesion; however, no rigorous approach exists to monitor and quantify it accurately in the absence of the confounding factors of cell-substrate adhesion and the re...

journal_title：Cancer research

authors： Saias L,Gomes A,Cazales M,Ducommun B,Lobjois V

更新日期：2015-06-15 00:00:00

abstract：:Cancer immunotherapy may become a major treatment backbone in many cancers over the next decade. There are numerous immune cell types found in cancers and many components of an immune reaction to cancer. Thus, the tumor has many strategies to evade an immune response. It has been proposed that four different types of ...

journal_title：Cancer research

authors： Teng MW,Ngiow SF,Ribas A,Smyth MJ

更新日期：2015-06-01 00:00:00

abstract：:Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Pharmacologic targeting of aneuploidy is an attractive therapeutic strategy, as this would preferentially eliminate malignant over normal cells. We previously discovered that CDK2 inhibition causes lung cancer cells with more than ...

journal_title：Cancer research

authors： Hu S,Danilov AV,Godek K,Orr B,Tafe LJ,Rodriguez-Canales J,Behrens C,Mino B,Moran CA,Memoli VA,Mustachio LM,Galimberti F,Ravi S,DeCastro A,Lu Y,Sekula D,Andrew AS,Wistuba II,Freemantle S,Compton DA,Dmitrovsky E

更新日期：2015-05-15 00:00:00

abstract：:Low income, poor diet, obesity, and a lack of exercise are interrelated lifestyle factors that can profoundly alter our biologic make up to increase cancer risk, growth, and development. We recently reported a potential mechanistic link between carbohydrate-derived metabolites and cancer, which may provide a biologic ...

journal_title：Cancer research

authors： Turner DP

更新日期：2015-05-15 00:00:00

abstract：:GPRC5A is a G-protein-coupled receptor expressed in lung tissue but repressed in most human lung cancers. Studies in Gprc5a(-/-) mice have established its role as a tumor-suppressor function in this setting, but the basis for its role has been obscure. Here, we report that GPRC5A functions as a negative modulator of E...

journal_title：Cancer research

authors： Zhong S,Yin H,Liao Y,Yao F,Li Q,Zhang J,Jiao H,Zhao Y,Xu D,Liu S,Song H,Gao Y,Liu J,Ma L,Pang Z,Yang R,Ding C,Sun B,Lin X,Ye X,Guo W,Han B,Zhou BP,Chin YE,Deng J

更新日期：2015-05-01 00:00:00

abstract：:Immune checkpoint inhibitors show great promise as therapy for advanced melanoma, heightening the need to determine the most effective use of these agents. Here, we report that programmed death-1(high) (PD-1(high)) tumor antigen (TA)-specific CD8(+) T cells present at periphery and at tumor sites in patients with adva...

journal_title：Cancer research

authors： Sun Z,Fourcade J,Pagliano O,Chauvin JM,Sander C,Kirkwood JM,Zarour HM

更新日期：2015-04-15 00:00:00

abstract：:Systemic chemotherapy generally has been considered immunosuppressive, but it has become evident that certain chemotherapeutic drugs elicit immunogenic danger signals in dying cancer cells that can incite protective antitumor immunity. In this study, we investigated whether locoregionally applied therapies, such as me...

journal_title：Cancer research

authors： Dudek-Perić AM,Ferreira GB,Muchowicz A,Wouters J,Prada N,Martin S,Kiviluoto S,Winiarska M,Boon L,Mathieu C,van den Oord J,Stas M,Gougeon ML,Golab J,Garg AD,Agostinis P

更新日期：2015-04-15 00:00:00

abstract：:The stability of several oncoproteins, including c-Myc, is regulated by ubiquitin-dependent degradation mediated by the SCF(Fbw7) ubiquitin ligase. This activity is antagonized by the deubiquitinase Usp28, which is highly expressed in murine and human intestinal cancers. Usp28 was previously shown to interact with its...

journal_title：Cancer research

authors： Diefenbacher ME,Chakraborty A,Blake SM,Mitter R,Popov N,Eilers M,Behrens A

更新日期：2015-04-01 00:00:00

abstract：:Excess production of the proinflammatory IL6 has both local and systemic tumor-promoting activity in many cancers, including ovarian cancer. However, treatment of advanced ovarian cancer patients with a neutralizing IL6 antibody yielded little efficacy in a previous phase II clinical trial. Here, we report results tha...

journal_title：Cancer research

authors： Milagre CS,Gopinathan G,Everitt G,Thompson RG,Kulbe H,Zhong H,Hollingsworth RE,Grose R,Bowtell DD,Hochhauser D,Balkwill FR

更新日期：2015-04-01 00:00:00

abstract：:One third of the patients with estrogen receptor α (ERα)-positive breast cancer who are treated with the antiestrogen tamoxifen will either not respond to initial therapy or will develop drug resistance. Endocrine response involves crosstalk between ERα and TGFβ signaling, such that tamoxifen nonresponsiveness or resi...

journal_title：Cancer research

authors： Busch S,Sims AH,Stål O,Fernö M,Landberg G

更新日期：2015-04-01 00:00:00

abstract：:TP53 is the most frequently altered gene in head and neck squamous cell carcinoma (HNSCC), with mutations occurring in over two thirds of cases; however, the predictive response of these mutations to cisplatin-based therapy remains elusive. In the current study, we evaluate the ability of the Evolutionary Action score...

journal_title：Cancer research

authors： Osman AA,Neskey DM,Katsonis P,Patel AA,Ward AM,Hsu TK,Hicks SC,McDonald TO,Ow TJ,Alves MO,Pickering CR,Skinner HD,Zhao M,Sturgis EM,Kies MS,El-Naggar A,Perrone F,Licitra L,Bossi P,Kimmel M,Frederick MJ,Lichtarge

更新日期：2015-04-01 00:00:00

abstract：:The increased proteolytic activity of membrane-bound and secreted proteases on the surface of cancer cells and in the transformed stroma is a common characteristic of aggressive metastatic prostate cancer. We describe here the development of an active site-specific probe for detecting a secreted peritumoral protease e...

journal_title：Cancer research

authors： LeBeau AM,Sevillano N,Markham K,Winter MB,Murphy ST,Hostetter DR,West J,Lowman H,Craik CS,VanBrocklin HF

更新日期：2015-04-01 00:00:00

abstract：:Prostate cancer subtypes are poorly defined and functional validation of drivers of ETS rearrangement-negative prostate cancer has not been conducted. Here, we identified an ETS(-) subtype of aggressive prostate cancer (ERG(-)MAP3K7(del)CHD1(del)) and used a novel developmental model and a cell line xenograft model to...

journal_title：Cancer research

authors： Rodrigues LU,Rider L,Nieto C,Romero L,Karimpour-Fard A,Loda M,Lucia MS,Wu M,Shi L,Cimic A,Sirintrapun SJ,Nolley R,Pac C,Chen H,Peehl DM,Xu J,Liu W,Costello JC,Cramer SD

更新日期：2015-03-15 00:00:00

abstract：:Tumor-initiating cells (TIC) perpetuate tumor growth, enable therapeutic resistance, and drive initiation of successive tumors. Virtually nothing is known about the role of mechanotransductive signaling in controlling TIC tumorigenesis, despite the recognized importance of altered mechanics in tissue dysplasia and the...

journal_title：Cancer research

authors： Wong SY,Ulrich TA,Deleyrolle LP,MacKay JL,Lin JM,Martuscello RT,Jundi MA,Reynolds BA,Kumar S

更新日期：2015-03-15 00:00:00

abstract：:The translation initiation factor eIF4E is an oncogene that is commonly overexpressed in primary breast cancers and metastases. In this article, we report that a pharmacologic inhibitor of eIF4E function, ribavirin, safely and potently suppresses breast tumor formation. Ribavirin administration blocked the growth of p...

journal_title：Cancer research

authors： Pettersson F,Del Rincon SV,Emond A,Huor B,Ngan E,Ng J,Dobocan MC,Siegel PM,Miller WH Jr

更新日期：2015-03-15 00:00:00

abstract：:Proliferating mammalian stem and cancer cells express telomerase [telomerase reverse transcriptase (TERT)] in an effort to extend chromosomal G-overhangs and maintain telomere ends. Telomerase-expressing cells also have higher levels of the single-stranded DNA-binding protein SSB1, which has a critical role in DNA dou...

journal_title：Cancer research

authors： Pandita RK,Chow TT,Udayakumar D,Bain AL,Cubeddu L,Hunt CR,Shi W,Horikoshi N,Zhao Y,Wright WE,Khanna KK,Shay JW,Pandita TK

更新日期：2015-03-01 00:00:00

abstract：:The endoplasmic reticulum aminopeptidase ERAP1 regulates innate and adaptive immune responses by trimming peptides for presentation by MHC class I (MHC-I) molecules. Herein, we demonstrate that genetic or pharmacological inhibition of ERAP1 on human tumor cell lines perturbs their ability to engage several classes of ...

journal_title：Cancer research

authors： Cifaldi L,Romania P,Falco M,Lorenzi S,Meazza R,Petrini S,Andreani M,Pende D,Locatelli F,Fruci D

更新日期：2015-03-01 00:00:00

abstract：:Pregnancy at early, but not late age, has a strong and life-long protective effect against breast cancer. The expected overall increase in breast cancer incidence demands the development of a pharmaceutical mimicry of early-age pregnancy-mediated protection. Recently, converging results from rodent models and women on...

journal_title：Cancer research

authors： Meier-Abt F,Bentires-Alj M,Rochlitz C

更新日期：2015-03-01 00:00:00

abstract：:Colitis-associated cancer (CAC) is a complication of inflammatory bowel disease (IBD). Binding of extracellular ATP to the purinergic receptor P2RX7 has emerged as a critical event in controlling intestinal inflammation, acting to limit elevation of proinflammatory mast cells and cytokines and promote survival of regu...

journal_title：Cancer research

authors： Hofman P,Cherfils-Vicini J,Bazin M,Ilie M,Juhel T,Hébuterne X,Gilson E,Schmid-Alliana A,Boyer O,Adriouch S,Vouret-Craviari V

更新日期：2015-03-01 00:00:00

abstract：:TP53 gene mutation is associated with poor prognosis in breast cancer, but additional biomarkers that can further refine the impact of the p53 pathway are needed to achieve clinical utility. In this study, we evaluated a role for the HDMX-S/FL ratio as one such biomarker, based on its association with other suppressor...

journal_title：Cancer research

authors： Grawenda AM,Møller EK,Lam S,Repapi E,Teunisse AF,Alnæs GI,Børresen-Dale AL,Kristensen VN,Goding CR,Jochemsen AG,Edvardsen H,Bond GL

更新日期：2015-02-15 00:00:00

abstract：:Crosstalk between tumor and stromal cells in the tumor microenvironment alter its properties in ways that facilitate the invasive behavior of tumor cells. Here, we demonstrate that cancer-associated fibroblasts (CAF) increase the stiffness of the extracellular matrix (ECM) and promote anisotropic fiber orientation, tw...

journal_title：Cancer research

authors： Stanisavljevic J,Loubat-Casanovas J,Herrera M,Luque T,Peña R,Lluch A,Albanell J,Bonilla F,Rovira A,Peña C,Navajas D,Rojo F,García de Herreros A,Baulida J

更新日期：2015-01-15 00:00:00

abstract：:Triple-negative breast cancers (TNBC), which include the basal-like and claudin-low disease subtypes, are aggressive malignancies for which effective therapeutic targets are lacking. NF-κB activation has an established role in breast malignancy, and it is higher in TNBC than other breast cancer subtypes. On this basis...

journal_title：Cancer research

authors： Ito-Kureha T,Koshikawa N,Yamamoto M,Semba K,Yamaguchi N,Yamamoto T,Seiki M,Inoue J

更新日期：2015-01-01 00:00:00

abstract：:Carcinoma cells can transition from an epithelial-to-mesenchymal differentiation state through a process known as epithelial-mesenchymal transition (EMT). The process of EMT is characterized by alterations in the pattern of gene expression and is associated with a loss of cell polarity, an increase in invasiveness, an...

journal_title：Cancer research

authors： Bogachek MV,De Andrade JP,Weigel RJ

更新日期：2015-01-01 00:00:00

abstract：:Metastatic cases of breast cancer pose the primary challenge in clinical management of this disease, demanding the identification of effective therapeutic strategies that remain wanting. In this study, we report that elevated levels of α-tubulin acetylation are a sufficient cause of metastatic potential in breast canc...

journal_title：Cancer research

authors： Boggs AE,Vitolo MI,Whipple RA,Charpentier MS,Goloubeva OG,Ioffe OB,Tuttle KC,Slovic J,Lu Y,Mills GB,Martin SS

更新日期：2015-01-01 00:00:00

abstract：:About two thirds of laryngeal cancers originate at the vocal cords. Early-stage detection of malignant vocal fold alterations, including a discrimination of premalignant lesions, represents a major challenge in laryngology as precancerous vocal fold lesions and small carcinomas are difficult to distinguish by means of...

journal_title：Cancer research

authors： Unger J,Lohscheller J,Reiter M,Eder K,Betz CS,Schuster M

更新日期：2015-01-01 00:00:00

abstract：:Myeloid cells are capable of promoting or eradicating tumor cells and the nodal functions that contribute to their different roles are still obscure. Here, we show that mice with myeloid-specific genetic loss of the NF-κB pathway regulatory kinase IKKβ exhibit more rapid growth of cutaneous and lung melanoma tumors. I...

journal_title：Cancer research

authors： Yang J,Hawkins OE,Barham W,Gilchuk P,Boothby M,Ayers GD,Joyce S,Karin M,Yull FE,Richmond A

更新日期：2014-12-15 00:00:00

abstract：:Metformin, a biguanide widely used in the treatment of type II diabetes, clearly exhibits antineoplastic activity in experimental models and has been reported to reduce cancer incidence in diabetics. There are ongoing clinical trials to evaluate its antitumor properties, which may relate to its fundamental activity as...

journal_title：Cancer research

authors： Gravel SP,Hulea L,Toban N,Birman E,Blouin MJ,Zakikhani M,Zhao Y,Topisirovic I,St-Pierre J,Pollak M

更新日期：2014-12-15 00:00:00

abstract：:Multiple myeloma is a cytogenetically/molecularly heterogeneous hematologic malignancy that remains mostly incurable, and the identification of a universal and relevant therapeutic target molecule is essential for the further development of therapeutic strategy. Herein, we identified that 3-phosphoinositide-dependent ...

journal_title：Cancer research

authors： Chinen Y,Kuroda J,Shimura Y,Nagoshi H,Kiyota M,Yamamoto-Sugitani M,Mizutani S,Sakamoto N,Ri M,Kawata E,Kobayashi T,Matsumoto Y,Horiike S,Iida S,Taniwaki M

更新日期：2014-12-15 00:00:00